The UBOMI BUHLE project aims to improve the quality of care provided to pregnant women and newborns, by developing a pregnancy exposure registry that assesses the performance of public health therapeutic interventions such as antiretroviral therapy and their impact on maternal and birth outcomes in South Africa. This initiative will prioritize the assessment of the safety of ARV use as treatment and in the Prevention of Mother to Child Transmission (PMTCT) program, while implementing a series of health systems strengthening initiatives that will contribute to the creation of a sustainable surveillance platform. The project will prioritise monitoring the performance of dolutegravir-based antiretroviral therapy and its impact on maternal and birth outcomes.  This work is being undertaken as a partnership between the provincial departments of health, academic institutions and supportive non-governmental organizations.